The Glucagon-Like Podcast: Navigating GLP-1 Receptor Agonists in Anesthesia

On This Episode:

Terry and Garry dive into the fascinating world of GLP-1 receptor agonists, those tiny molecules that can be both a blessing and a potential risk factor when it comes to anesthesia. In this episode, we’re going embark on a journey through the world of diabetes management, how it intersects with the realm of anesthesia and what the implications are for providers in the operating room.

And in the perioperative period, we’re going to shine a spotlight on these new agents, explore their effects, and we’re going to discuss the challenges they present to our CRNA colleagues.

So stay with us as we navigate through the complexities of these medications and their implications for anesthesia practice. It’s a critical topic today. And we’re here to provide insights, understanding, and perhaps a little comedy.

Here’s some of what we discuss in this episode:

  • How SGLT2 inhibitors help with diabetes management.
  • The basics of the GLP-1 receptor agonists.
  • Examples of GLP-1 receptor agonists on the market today.
  • Anesthesia considerations that need to be addressed.
  • Unpacking Cyclopentenophenanthrene.
  • Looking at the study: Characteristics and outcomes of patients hospitalized following a pulmonary aspiration.


Resources for this episode:

Beam, W. & Guevera, L. (2023). Are Serious Anesthesia Risks of Semaglutide and Other GLP-1 Agonists Under-Recognized? Case Reports of Retained Solid Gastric Contents in Patients Undergoing Anesthesia. Retrieved from:


Dzaye, O., Berning, P., Razavi, A. C., Adhikari, R., Jha, K., Nasir, K., Ayers, J. W., Mortensen, M. B., & Blaha, M. J. (2022). Online searches for SGLT-2 inhibitors and GLP-1 receptor agonists correlate with prescription rates in the United States: An infodemiological study. Frontiers in Cardiovascular Medicine, 9, 936651–936651.  


Flynn, D., Doyal, A., & Schoenherr, J. (2023). Gastric Ultrasound. Retrieved from:


Hurren, K. M., & Pinelli, N. R. (2012). Drug-Drug Interactions with Glucagon-Like Peptide-1 Receptor Agonists. The Annals of Pharmacotherapy, 46(5), 710–717.


Lee, A., Festic, E., Park, P. K., Raghavendran, K., Dabbagh, O., Adesanya, A., Gajic, O., & Bartz, R. R. (2014). Characteristics and Outcomes of Patients Hospitalized Following Pulmonary Aspiration. Chest, 146(4), 899–907.


Mitina, A. (2023). New guidance suggests skipping Ozempic before surgery

Have surgery coming up? Talk to your doctor about pausing Ozempic. Retrieved from:  

Perlas, A, & Kruisselbrink, R. (2021). POCUS Spotlight: Gastric Ultrasound. Retrieved from:


Sanivarapu, R. & Gibson, J. (2023). Aspiration Pneumonia. Retrieved from:


Van de Putte, P. & Bouvet, L. (2023). Gastric volume assessment (clear fluids). Retrieved from:


Vigara, L. A., Villanego, F., Orellana, C., Naranjo, J., Torrado, J., Garcia, T., & Mazuecos, A. (2022). Effectiveness and safety of glucagon‐like peptide‐1 receptor agonist in a cohort of kidney transplant recipients. Clinical Transplantation, 36(5), e14633–n/a.


Help us grow by leaving a review:


GLP-1 receptor agonists are like the slow motion button for your stomach. And this is really a critical point. They slow down gastric emptying, keeping those post-dinners sugar surprises in check, and a few other benefits like appetite suppression, cardiovascular and renal benefits to boot.





CRNA Careers

Nurturing Knowledge with Thanks

As we celebrate another Thanksgiving, we want to show our appreciation for an organization that does so much for CRNAs. Many people don’t know about the AANA Foundation’s purpose and why it’s important to individual CRNAs working in the OR, but they play a critical role in supporting and growing the profession. Today we’ll spend time with Executive Director Nat Carmichael and Treasurer Mike Anderson, DNP, CRNA to learn more about the best kept secret in our profession.

CRNA Careers

Advocacy in Nurse Anesthesiology Training with Dr. Kristie Hoch

We pose the question to guests all the time about how to get more CRNAs involved on the advocacy side of the profession, but today’s guest is taking a hands-on approach to instilling that mindset at the educational level. Dr. Kristie Hoch has taken her passion for advocacy and applied it to the nurse anesthesiology program at the University of Arizona. Together with co-host Tracy Castleman, DNP, CRNA, APN-A, FAANA, we will hear all about her training process and why she thinks this leadership training will pay off in all aspects of their careers.




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J. Cross CRNA
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This podcast is very well put together. I love the hosts Sharon & Jeremy, they do a fantastic job at presenting topics as well as getting great speakers on the show! This is my morning commute podcast everyday! Thank you for all that you do!
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I enjoy listening every morning. Great content and always a pleasure to learn something new.
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I started listening to this podcast religiously early on in my CRNA journey, a year before applying to CRNA school. The content in this podcast was one of my most helpful resources for getting into my first choice school, Wake Forest! It has also been a huge motivator for getting involved with the AANA now and throughout my career. I highly recommend this podcast to every prospective CRNA I meet.
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I appreciate hearing the latest and greatest in the world of Nurse Anesthesiology while also getting Class B credits. Just listen on your commute for a win/win experience. I love the perspectives from Jeremy and Sharon who both ask varied and insightful questions!
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If you’re a CRNA or any medical professional, I highly recommend giving this podcast a listen. Hosts have a great rapport.